Aug 21, 2018 bilirubin is a byproduct of red blood cell destruction and are conjugated in the liver and excreted in bile. Data should be separated in coma, space, tab, or in separated lines. Molecular and functional characterization of microsomal udpglucuronic acid uptake by members of the nucleotide sugar. Get a printable copy pdf file of the complete article 2. Metabolism of bilirubin and its biological properties. Kadar bilirubin dalam serum dipengaruhi oleh metabolisme hemoglobin, fungsi hati dan kejadiankejadian pada saluran empedu.
Doc metabolisme bilirubin fironika ariyanti academia. Describe the physiology of bilirubin production, metabolism and clearance 70% of marks. The heme portion from hemoglobin and from other hemecontaining proteins is removed, metabolized to bilirubin, and transported as a complex with serum albumin to the liver. My physician for years has attributed the elevated readings to gilberts syndrome. Bilirubin metabolism article about bilirubin metabolism by. What is the highest serum biliruin you have ever seen in. Ppt bilirubin metabolism powerpoint presentation free. I have always had high levels but the annual reads were consistently around 2.
Hereditary jaundice and disorders of bilirubin metabolism in stanbury, et al eds. Feb 22, 2015 a short video showing how jaundice arises in the neonate and detailing the role of phototherapy. This catabolism is a necessary process in the bodys clearance of waste products that arise from the destruction of aged or abnormal red blood cells. Bilirubin is the ultimate breakdown product of haemoglobin and serves asadiagnosticmarkerofliver and blood disorders. Bilirubin formation 80% of bilirubin degradation of the hemoglobin 2 old or injured rbcs. Bilirubin metabolism and its role in neonatal jaundice. Winner of the standing ovation award for best powerpoint templates from presentations magazine. Sel retikuloendotel membuat bilirubin tak larut air, bilirubin yang sekresikan ke dalam darah diikat albumin untuk diangkut dalam plasma. Bilirubin metabolism article about bilirubin metabolism.
If the bilirubin in the blood is too high hyperbilirubinemia, it leads to jaundice or icterus, which is the yellowish discoloration of the skin, sclera. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. When bilirubin is excreted by the gallbladder, the bile saponifies fat rendering is more easily digested by. You have not told us that value, and it is required to make the diagnosis of gilberts. Bilirubin metabolism definition of bilirubin metabolism by. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. Bilirubin br is a yellow compound that occurs in the normal catabolic pathway that breaks down heme in vertebrates. The fast metabolism diet is a strategic 28day plan to nurture the body back to health. In the circulation, bilirubin is bound to albumin and transported as a bilirubin albumin complex into the liver. Bilirubin can increase in dehydrated states to the extent your has in the blood tests.
Very recently, bilirubin has been shown to possess important functions as an antioxidant, but it also serves simply as a means to excrete unwanted heme, derived from various hemecontaining proteins such as hemoglobin, myoglobin, and various p450 enzymes. Total bilirubin definition of total bilirubin by medical. First thing to do is to find out if it is direct or indirect or both types of bilirubin that are elevated. My physician for years has attributed the elevated readings to. Increased levels are associated with conditions causing obstruction of the bile duct, hepatitis, cirrhosis, hemolytic disorders, physiological jaundice of the newborn and several inherited. Bilirubin is enzymatically formed from heme via biliverdin. It is the main pigment which is responsible for the color of bile, feces and urine. Metabolisme bilirubin diawali dengan reaksi proses pemecahan heme oleh enzim hemoksigenase yang mengubah biliverdin menjadi bilirubin oleh enzim. Liver bilirubin metabolism jaundice linkedin slideshare. The highest level of the serum bilirubin i have ever seen was slightly more than 500 mcmoll about 30 mgdl in case of the intrahepatic fistula between a large bile duct and a branch of the vena. Bilirubin is a yellow breakdown product of normal heme catabolism. Bilirubin enters hepatocytes, and binds to ligandin, uptake of bilirubin into hepatocytes increases with increasing ligandin concentration, ligandin concentration is low at birth, but increases rapidly over the first few weeks of life, bilirubin is removed from albumin and taken up at the.
Your doctor can order a fractionalized bilirubin test which gives values for each component rather than merely the sum of the two. Bilirubin is a metabolite of heme, a compound that serves to coordinate iron in various proteins. Diseases that cause liver damage can lead to increased bilirubin levels. Just got lab results back that showed total bilirubin at 3. Bilirubin is the potentially toxic catabolic product of heme metabolism. Evaluation of jaundice bilirubin metabolism physiology and biochemistry clinical evaluation adult, child, infant, and pregnant woman postoperative jaundice 1. Metabolisme bilirubin dimulai oleh penghancuran eritrosit setelah usia 120 hari oleh sistem retikuloendotel menjadi heme dan globin. Bilirubin is a byproduct of red blood cell breakdown in the. Total bilirubin consists of both conjugated direct and unconjugated indirect fractions. Bilirubin is a family of orangeyellow pigments produced from the breakdown of the heme group in the red blood cells.
C biliverdin biliverdin reductase hb in the plasma bilirubin haptoglobin extravascular hemolysis unconjugated bilirubin bilirubin in blood blood intravascular hemolysis 10. Please have a look at the test haematology profile red blood cells haemoglobin 15. Bilirubin is produced from the catabolism of the heme molecule. The total bilirubin less the direct bilirubin is the indirect or unconjugated bilirubin. In the circulation, bilirubin is bound to albumin and. Bilirubin is formed in the reticuloendothelial system during the degradation of aged erythrocytes. Sekitar 85% heme yang didegradasi berasal dari eritrosit dan 15% berasal dari jaringan ekstraeritroid. Hi doctor, i done a lever function test today test results mentionef below total bilirubin 1. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. It uses targeted nutrients at strategic times to evoke a metabolic change in a body thats stuck or has become sluggish at burning fat. Proses metabolisme pemecahan heme sangatlah kompleks.
Ppt bilirubin metabolism powerpoint presentation free to. The content on this site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. Bilirubin, total conversion to mmoll, moll, mgdl, mg. Your doctor can order a fractionalized bilirubin test which gives values for each component rather than merely the. Metabolisme bilirubin proses metabolisme pemecahan heme sangatlah kompleks. Liver function test results elevated total bilirubin doctor. A deposition of excess bilirubin in the body is known as hyperbilirubinemia.
Its levels are elevated in certain diseases and it is responsible for the yellow colour of bruises and the brown colour of feces. Bilirubin entry into the brain is dependent on the integrity of the bloodbrain barrier, and its persistence in the brain is determined by a variety of transporters as well as by bilirubin metabolism. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Links to pubmed are also available for selected references.
It is present in small quantities in the plasma of vertebrate animals and man 0. Biliverdin yang larut dalam air kemudian akan direduksi menjadi bilirubin oleh enzim biliverdin reduktase. It has a complex metabolism, which is important in relation to several processes involved in drug metabolism. Fortunately, there are elaborate physiologic mechanisms for its detoxification and disposition. Outline the changes in blood and urine of the products of bilirubin metabolism with intra and post hepatobiliary disease 30% of marks.
Perbandingan kadar bilirubin neonatus dengan dan tanpa defisiensi glucose 6. Setelah kurang lebih 120 hari, eritrosit diambil dan didegradasi oleh sistem. Metabolisme bilirubin blok 11 2016 free download as powerpoint presentation. Alur metabolisme pemecahan heme dan pembentukan bilirubin. Get a printable copy pdf file of the complete article 589k, or click on a page image below to browse page by page. The latter catabolic changes in the structure of tetrapyrroles are responsible for the progressive changes in color of a hematoma, or bruise, in which the damaged tissue changes its color from an initial dark blue to a redyellow and finally to a yellow. Now if the indirect is very elevated with fairly normal direct bilirubin up to 0. Langkah oksidase pertama adalah biliverdin yang dibentuk dari heme dengan bantuan enzim heme oksigenase yaitu enzim yang sebagian besar terdapat dalam sel hati, dan organ lain. Consider that your liver is a massive organ with so many crucial responsibilities, including. C biliverdin biliverdin reductase hb in the plasma bilirubin haptoglobin extravascular hemolysis unconjugated bilirubin bilirubin in. Understanding these mechanisms is necessary for interpretation of the clinical significance of high serum bilirubin concentrations.
First the hemoglobin gets stripped of the heme molecule which thereafter passes through various processes of porphyrin catabolism. An excess in unconjugated bilirubin in the serum of the neonate causes a yellowish discoloration in the skin, a greenish or brown stool and may collect in the basal ganglia of the brain and cause kernicterus. Setelah kurang lebih 120 hari, eritrosit diambil dan didegradasi oleh sistem res terutama di hati dan limpa. Bilirubin is degraded in the intestine by bacteria into urobilinogens, which are partly excreted in the urine. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease. Bab ii proses metabolisme pemecahan heme sangatlah. It is common in neonates and is manifested by neonatal jaundice. Bilirubin levels high and low, blood test in adults. Increased production, reduced uptake and low glucuronidation capacity can increase plasma unconjugated bilirubin levels. C hb globin cells of the reticular endothelial system.
Thus, it is unlikely that tcb measurements will provide a better measure of risk for developing kernicterus in the context of high tsb. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Bilirubin metabolism definition of bilirubin metabolism. Bilirubin udpglucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man. Sebagian besar produksi bilirubin merupakan akibat degradasi hemoglobin pada sistem retikuloendotelial. Bilirubin levels chart normal, low, high bilirubin levels. Full text full text is available as a scanned copy of the original print version. Bilirubin is a bit high but nothing alarming and your alk phosphatase is 39 while the normal limit is 40 so that is not alarming as well and such variations are expected. To further investigate the cause of jaundice or increased bilirubin levels, liver function tests or other evidence of infective hepatitis hepatitis a, b, c, delta, e, etc. It incorporates healthy whole foods and all of the food groups but in a way that rotates between rest and restoration and. Increased levels are associated with conditions causing obstruction of the bile duct, hepatitis, cirrhosis, hemolytic disorders, physiological jaundice of the newborn and several inherited enzyme deficiencies.
High bilirubin can be due to liver disease, hemolysis, biliary obstruction and the treatment is dictated by the cause of the abnormality. Metabolisme bilirubin meliputi sintesis, transportasi, intake dan konjugasi serta ekskresi. Bilirubin reduction in the gut leads to a product called urobilinogen, which is excreted in urine. Learn vocabulary, terms, and more with flashcards, games, and other study tools.